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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACTL8
All Species:
31.82
Human Site:
Y238
Identified Species:
58.33
UniProt:
Q9H568
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H568
NP_110439.2
366
41360
Y238
A
L
D
E
S
N
T
Y
Q
L
P
D
G
S
R
Chimpanzee
Pan troglodytes
XP_001156798
366
41310
Y238
A
L
D
E
S
N
T
Y
Q
L
P
D
G
S
R
Rhesus Macaque
Macaca mulatta
XP_001090405
366
41293
Y238
G
L
D
E
S
N
T
Y
Q
L
P
D
G
S
R
Dog
Lupus familis
XP_544535
432
48309
Y304
G
S
D
E
N
N
T
Y
Q
L
P
D
G
T
P
Cat
Felis silvestris
Mouse
Mus musculus
Rat
Rattus norvegicus
P68035
377
42000
Y242
S
S
S
L
E
K
S
Y
E
L
P
D
G
Q
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515705
376
41051
K241
A
P
S
I
K
T
Y
K
L
P
D
G
N
A
I
Chicken
Gallus gallus
P68139
377
42033
Y242
S
S
S
L
E
K
S
Y
E
L
P
D
G
Q
V
Frog
Xenopus laevis
P04751
377
41997
Y242
S
S
S
L
E
K
S
Y
E
L
P
D
G
Q
V
Zebra Danio
Brachydanio rerio
NP_001002066
377
41986
Y242
S
S
S
L
E
K
S
Y
E
L
P
D
G
Q
V
Tiger Blowfish
Takifugu rubipres
P53480
377
41956
Y242
S
S
S
L
E
K
S
Y
E
L
P
D
G
Q
V
Fruit Fly
Dros. melanogaster
P02574
376
41768
Y241
S
T
S
L
E
K
S
Y
E
L
P
D
G
Q
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_508841
376
41759
Y241
S
S
S
L
E
K
S
Y
E
L
P
D
G
Q
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
NP_116614
375
41671
Y240
S
S
S
I
E
K
S
Y
E
L
P
D
G
Q
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
97.5
66.4
N.A.
N.A.
32.8
N.A.
32.7
33.1
32.8
32.8
32.8
32.1
N.A.
32.7
N.A.
Protein Similarity:
100
100
98.3
75.4
N.A.
N.A.
51.1
N.A.
52.3
51.7
51.4
51.1
51.1
52.1
N.A.
51.3
N.A.
P-Site Identity:
100
100
93.3
66.6
N.A.
N.A.
33.3
N.A.
6.6
33.3
33.3
33.3
33.3
33.3
N.A.
33.3
N.A.
P-Site Similarity:
100
100
93.3
80
N.A.
N.A.
53.3
N.A.
13.3
53.3
53.3
53.3
53.3
53.3
N.A.
53.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
53
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
24
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
31
0
0
0
0
0
0
0
8
93
0
0
0
% D
% Glu:
0
0
0
31
62
0
0
0
62
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
16
0
0
0
0
0
0
0
0
0
0
8
93
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
16
0
0
0
0
0
0
0
0
0
0
8
% I
% Lys:
0
0
0
0
8
62
0
8
0
0
0
0
0
0
0
% K
% Leu:
0
24
0
54
0
0
0
0
8
93
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
31
0
0
0
0
0
0
8
0
0
% N
% Pro:
0
8
0
0
0
0
0
0
0
8
93
0
0
0
8
% P
% Gln:
0
0
0
0
0
0
0
0
31
0
0
0
0
62
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
24
% R
% Ser:
62
62
70
0
24
0
62
0
0
0
0
0
0
24
0
% S
% Thr:
0
8
0
0
0
8
31
0
0
0
0
0
0
8
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
62
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
93
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _